About the Authors

Patrick Meagher

Roles Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

‡ These authors are co-first authors on this work.

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Department of Physiology, University of Toronto, Toronto, Canada

Robert Civitarese

Roles Data curation, Formal analysis, Visualization, Writing – original draft

‡ These authors are co-first authors on this work.

Affiliation St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada

Xavier Lee

Roles Formal analysis, Writing – original draft

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Department of Physiology, University of Toronto, Toronto, Canada

Mark Gordon

Roles Data curation, Formal analysis

Affiliation St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada

Antoinette Bugyei-Twum

Roles Data curation, Formal analysis, Project administration, Supervision

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Department of Physiology, University of Toronto, Toronto, Canada

Jean-Francois Desjardins

Roles Formal analysis, Methodology, Software, Writing – review & editing

Affiliation St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada

Golam Kabir

Roles Investigation, Methodology

Affiliation St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada

Yanling Zhang

Roles Investigation, Methodology

Affiliation St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada

Hari Kosanam

Roles Investigation, Methodology, Software

Affiliation St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada

Aylin Visram

Roles Data curation, Formal analysis

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Department of Physiology, University of Toronto, Toronto, Canada

Howard Leong-Poi

Roles Conceptualization, Investigation, Writing – review & editing

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

Andrew Advani

Roles Conceptualization, Methodology, Writing – review & editing

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

Kim A. Connelly

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

ConnellyK@smh.ca

Affiliations St. Michael’s Hospital, Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Canada, Department of Physiology, University of Toronto, Toronto, Canada, Institute of Medical Science, University of Toronto, Toronto, Canada

Competing Interests

The authors have read the journal’s policy and have the following competing interests: KAC has received research grants to his institution from Astra Zeneca and Boehringer Ingelheim, received support for travel to scientific meeting from Boehringer Ingelheim, and received honoraria for speaking engagements and ad hoc participation in advisory boards from Astra Zeneca, Boehringer Ingelheim, and Janssen. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.