About the Authors

Brian E. Lacy

Roles Investigation, Writing – original draft, Writing – review & editing

Lacy.Brian@mayo.edu

Affiliation Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, FL, United States of America

Elizabeth P. Shea

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation Medical Writing and Publications, Ironwood Pharmaceuticals, Inc., Boston, MA, United States of America

Machelle Manuel

Roles Writing – review & editing

Affiliation Ironwood Pharmaceuticals, Inc., Boston, MA, United States of America

Jessica L. Abel

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Affiliation Global Health Economics & Outcomes Research, AbbVie Inc., Madison, NJ, United States of America

Hancheng Jiang

Roles Formal analysis, Writing – review & editing

Affiliation Ironwood Pharmaceuticals, Inc., Boston, MA, United States of America

Douglas C. A. Taylor

Roles Conceptualization, Formal analysis, Validation, Writing – original draft, Writing – review & editing

Affiliation Health Economics & Outcomes Research, Ironwood Pharmaceuticals, Inc., Boston, MA, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: Brian E. Lacy is a participant on the scientific advisory boards of Allergan plc (prior to acquisition by AbbVie Inc.), Ironwood Pharmaceuticals, Inc., Salix, and Takeda. Elizabeth P. Shea and Douglas C.A. Taylor are employees of Ironwood Pharmaceuticals, Inc. and hold stock and stock options. Hancheng Jiang and Machelle Manuel are former employees of Ironwood Pharmaceuticals, Inc. and may hold stock. Jessica L. Abel is an employee of AbbVie Inc. and holds stock and stock options. This does not alter our adherence to PLOS ONE policies on sharing data and materials.