Familial Alzheimer’s disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system

Christian Tackenberg; Luka Kulic; Roger M. Nitsch

doi:10.1371/journal.pone.0239584

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Open Access

Peer-reviewed

Research Article

Familial Alzheimer’s disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system

Christian Tackenberg ,

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: christian.tackenberg@irem.uzh.ch

Affiliations Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

http://orcid.org/0000-0002-0019-3055

⨯
Luka Kulic,

Roles Conceptualization, Methodology

Affiliations Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland
⨯
Roger M. Nitsch

Roles Conceptualization, Supervision

Affiliations Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland
⨯

Familial Alzheimer’s disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system

Christian Tackenberg,
Luka Kulic,
Roger M. Nitsch

Published: September 23, 2020
https://doi.org/10.1371/journal.pone.0239584

About the Authors

Christian Tackenberg

Roles Conceptualization, Data curation, Funding acquisition, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: christian.tackenberg@irem.uzh.ch

Affiliations Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

http://orcid.org/0000-0002-0019-3055

Luka Kulic

Roles Conceptualization, Methodology

Affiliations Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

Roger M. Nitsch

Roles Conceptualization, Supervision

Affiliations Institute for Regenerative Medicine, University of Zurich, Schlieren, Switzerland, Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

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Mouse models
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Toxicity
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Neuronal dendrites
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Genetically modified animals
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Phosphorylation
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Alzheimer's disease
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Hippocampus
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Cell death
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