About the Authors

Yuji Ishida

Roles Conceptualization, Investigation, Writing – original draft

Affiliations Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan, Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Hiroshima, Japan

Chihiro Yamasaki

Roles Investigation, Writing – original draft

Affiliation Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

Hiroko Iwanari

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Quantitative Biology and Medicine, Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Meguro, Tokyo, Japan

Hisahiko Yamashita

Roles Investigation, Methodology

Affiliation Institute of Immunology Co., Ltd., Bunkyo, Tokyo, Japan

Yuko Ogawa

Roles Formal analysis

Affiliation Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

Ami Yanagi

Roles Investigation

Affiliation Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

Suzue Furukawa

Roles Investigation

Affiliation Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

Yuha Kojima

Roles Writing – original draft, Writing – review & editing

Affiliation Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

Kazuaki Chayama

Roles Resources

Affiliations Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Hiroshima, Japan, Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan

Junichi Kamiie

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan

Chise Tateno

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

chise.mukaidani@phoenixbio.co.jp

Affiliations Department of Research and Development, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan, Research Center for Hepatology and Gastroenterology, Hiroshima University, Hiroshima, Hiroshima, Japan

Competing Interests

The authors of this manuscript have read the journal's policy and have the following competing interests: YI, CY, YO, AY, SF, YK, CT are paid employees of PhoenixBio Co., Ltd. HI, HY are paid employees of Institute of Immunology Co., Ltd. This does not alter our adherence to PLOS ONE policies on sharing data and materials. PXB-mice and PXB-cells are products of PhoenixBio Co., Ltd.