About the Authors

Magdielis Gregory Rivera

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Alana C. Sampson

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – review & editing

Affiliation Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Pamela S. Hair

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Haree K. Pallera

Roles Data curation, Formal analysis, Software, Validation

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Kaitlyn G. Jackson

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – review & editing

Affiliation Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Adrianne I. Enos

Roles Methodology

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Turaj Vazifedan

Roles Formal analysis, Validation

Affiliations Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Children’s Hospital of The King’s Daughters, Norfolk, Virginia, United States of America

Alice L. Werner

Roles Formal analysis, Methodology, Supervision, Validation

Affiliations Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Children’s Hospital of The King’s Daughters, Norfolk, Virginia, United States of America, Children’s Specialty Group, Norfolk, Virginia, United States of America

Corinne L. Goldberg

Roles Supervision, Writing – original draft

Affiliation American Red Cross, Durham, North Carolina, United States of America

Frank A. Lattanzio

Roles Project administration, Supervision

Affiliation Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Kenji M. Cunnion

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft

Affiliations Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Children’s Hospital of The King’s Daughters, Norfolk, Virginia, United States of America, Children’s Specialty Group, Norfolk, Virginia, United States of America

Neel K. Krishna

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

krishnnk@evms.edu

Affiliations Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: In addition to their academic appointments, Neel K Krishna and Kenji M Cunnion are officers of ReAlta Life Sciences, Inc. guiding the development of PIC1 molecules for clinical applications. ReAlta Life Sciences was founded by Eastern Virginia Medical School, Children’s Hospital of the King’s Daughters and Eriko Life Science Ventures. Oversight for potential conflict of interest is provided by Eastern Virginia Medical School Conflict of Interest Committee. Neel K Krishna and Kenji M Cunnion are listed as inventors on patents that describe PIC1 molecules. The authors would like to declare the following patents/patent applications associated with this research: 8,241,843 methods for regulating complement cascade proteins using astrovirus coat protein and derivatives thereof, 15/738,786 synthetic peptide compounds and methods of use,16/400,486 synthetic peptide compounds and methods of use, 8,906,845 peptide compounds to regulate the complement system, 9,422,337 peptide compounds to regulate the complement system, 10,005,818 derivative peptide compounds and methods of use, 9,914,753 peptide compounds to regulate the complement system, 10,414,799 peptide compounds to regulate the complement system, 16/534,200 peptide compounds to regulate the complement system, 16/242,550 pic1 inhibition of myeloperoxidase oxidative activity in an animal model. Additionally, Dr. Cunnion is a Board member for Eriko Life Science Ventures and ReAlta Life Sciences, Inc. This does not alter our adherence to PLOS ONE policies on sharing data and materials.