About the Authors

Sumiko Ikari

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Center for Frontier Oral Science, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Shiou-Ling Lu

Roles Investigation

Affiliation Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan

Feike Hao

Roles Methodology

Affiliations Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan, China National Research Institute of Food and Fermentation Industries, Beijing, China

Kenta Imai

Roles Supervision

Affiliation Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Yasuhiro Araki

Roles Methodology

Affiliation Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan

Yo-hei Yamamoto

Roles Methodology

Affiliation Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan

Chao-Yuan Tsai

Roles Resources

Affiliation Laboratory of Immune Regulation, Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

Yumi Nishiyama

Roles Investigation

Affiliation Medicinal Botanical Garden, Kobe Pharmaceutical University, Kobe, Hyogo, Japan

Nobukazu Shitan

Roles Conceptualization, Methodology

Affiliation Laboratory of Medicinal Cell Biology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan

Tamotsu Yoshimori

Roles Conceptualization

Affiliation Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan

Takanobu Otomo

Roles Conceptualization, Methodology, Supervision

Affiliation Department of Molecular and Genetic Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan

Takeshi Noda

Roles Data curation, Supervision, Validation, Writing – original draft, Writing – review & editing

takenoda@dent.osaka-u.ac.jp

Affiliations Center for Frontier Oral Science, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan, Center for Frontier Oral Science, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan

Competing Interests

Takeshi NODA has received research grant from Tsumura CO. LTD. Tsumura CO LTD has no role in the study design; collection, analysis, and interpretation of data; writing of the paper; and decision to submit for publication. This research is not related to any of employment, consultancy, patents, products in development of Tsumura CO. LTD. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. The other authors have nothing to disclose.