About the Authors

Isao Murakami

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Kosaku Murakami

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision

kosaku@kuhp.kyoto-u.ac.jp

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Motomu Hashimoto

Roles Supervision

Affiliation Department of the Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Masao Tanaka

Roles Supervision

Affiliation Department of the Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Hiromu Ito

Roles Supervision

Affiliation Department of Orthopedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Takao Fujii

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Wakayama Medical University, Wakayama, Japan

Mie Torii

Roles Supervision

Affiliation Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Kaori Ikeda

Roles Supervision

Affiliation Department of Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Akiko Kuwabara

Roles Supervision

Affiliation Department of Clinical Nutrition, Faculty of Comprehensive Rehabilitation, Osaka Prefecture University, Osaka, Japan

Kiyoshi Tanaka

Roles Supervision

Affiliation Department of Faculty of Nutrition, Kobe Gakuin University, Hyogo, Japan

Akiko Yoshida

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Shuji Akizuki

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Ran Nakashima

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Hajime Yoshifuji

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Koichiro Ohmura

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Takashi Usui

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Satoshi Morita

Roles Supervision

Affiliation Depatment of Biomedical Statistics and Bioinformatics, Kyoto University, Kyoto, Japan

Tsuneyo Mimori

Roles Supervision

Affiliation Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Competing Interests

I.M. has declared no conflicts of interests. K.M. has received speaking fees, and/or consulting fees from Eisai Co. Ltd. M.H. received research grant and/or speaker fee from Astellas, Eisai, Tanabe-Mitsubishi, and Brystol-Meyers. T. M. received research grants and/or speaking fees from Asahikasei Pharma Corp., Astellas Pharma Inc., AYUMI Pharmaceutical Corp., Bristol-Myers Squibb, Chugai Pharmaceutical Co, Ltd., Diaichi-Sankyo Co.,Ltd., Eisai Co., Ltd., Eli Lilly Japan K.K., Mitsubishi-Tanabe Pharma Co., Pfizer Japan Inc., Sanofi K.K. and Takeda Pharmaceutical Co., Ltd.. These companies had no role in the design of the study, the collection or analysis of the data, the writing of the manuscript or decision to submit the manuscript for the publication. This does not alter our adherence to PLOS ONE policies on sharing data and materials.