About the Authors

Cynthia Huang Bartlett

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Cynthia.Huang@pfizer.com

Affiliation Pfizer Inc, New York, NY, United States of America

Jack Mardekian

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Pfizer Inc, New York, NY, United States of America

Matthew James Cotter

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Pfizer Inc, New York, NY, United States of America

Xin Huang

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Pfizer Inc, New York, NY, United States of America

Zhe Zhang

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Pfizer Inc, New York, NY, United States of America

Christina M. Parrinello

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Flatiron Health, New York, NY, United States of America

Ariel Bulua Bourla

Contributed equally to this work with: Cynthia Huang Bartlett, Jack Mardekian, Matthew James Cotter, Xin Huang, Zhe Zhang, Christina M. Parrinello, Ariel Bulua Bourla

Roles Conceptualization, Formal analysis, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Flatiron Health, New York, NY, United States of America

Competing Interests

I have read the journal's policy and wish to report the following conflicts: Cynthia Huang Bartlett is a former employee of and owns stock in Pfizer Inc. Jack Mardekian, Matthew James Cotter, Xin Huang, and Zhe Zhang are employees of and own stock in Pfizer Inc. Christina M. Parrinello, and Ariel Bulua Bourla are employees of Flatiron Health, Inc., which is an independent subsidiary of the Roche Group, and which received funding from Pfizer for the conduct of this study; they also report equity ownership in Flatiron Health Inc. All authors affirm that these competing interests do not alter our adherence to PLOS ONE policies on sharing data and materials.