About the Authors

Sarah A. Pendergrass

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Genentech, Inc., South San Francisco, California, United States of America

Steven Buyske

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – review & editing

Affiliations Department of Statistics, Rutgers University, Piscataway, New Jersey, United States of America, Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Janina M. Jeff

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Illumina, Inc., San Diego, California, United States of America

Alex Frase

Roles Data curation, Methodology, Software, Visualization, Writing – review & editing

Affiliation Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Scott Dudek

Roles Data curation, Methodology, Project administration, Software, Visualization, Writing – review & editing

Affiliation Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Yuki Bradford

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – review & editing

Affiliation Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Jose-Luis Ambite

Roles Data curation, Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation Information Sciences Institute; University of Southern California, Marina del Rey, California, United States of America

Christy L. Avery

Roles Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America

Petra Buzkova

Roles Data curation, Formal analysis, Project administration, Writing – review & editing

Affiliation Department of Biostatistics, University of Washington, Seattle, Washington, United States of America

Ewa Deelman

Roles Data curation, Project administration, Resources, Writing – review & editing

Affiliation Information Sciences Institute; University of Southern California, Marina del Rey, California, United States of America

Megan D. Fesinmeyer

Roles Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation Amgen, Thousand Oaks, California, United States of America

Christopher Haiman

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

Gerardo Heiss

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

Lucia A. Hindorff

Roles Funding acquisition, Project administration, Resources, Writing – review & editing

Affiliation National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Chun-Nan Hsu

Roles Conceptualization, Data curation, Project administration, Resources, Writing – review & editing

Affiliation Center for Research in Biological Systems, Department of Neurosciences, University of California, San Diego, La Jolla, California, United States of America

Rebecca D. Jackson

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation The Ohio State University, Columbus, Ohio, United States of America

Yi Lin

Roles Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Loic Le Marchand

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

Tara C. Matise

Roles Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

Kristine R. Monroe

Roles Conceptualization, Data curation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

Larry Moreland

Roles Data curation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Kari E. North

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

Sungshim L. Park

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

Alex Reiner

Roles Formal analysis, Project administration, Supervision, Writing – review & editing

Affiliation Department of Epidemiology, University of Washington, Seattle, Washington, United States of America

Robert Wallace

Roles Data curation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Departments of Epidemiology and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Lynne R. Wilkens

Roles Data curation, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

Charles Kooperberg

Roles Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Marylyn D. Ritchie

Contributed equally to this work with: Marylyn D. Ritchie, Dana C. Crawford

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics, Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Dana C. Crawford

Contributed equally to this work with: Marylyn D. Ritchie, Dana C. Crawford

Roles Conceptualization, Funding acquisition, Investigation, Writing – review & editing

dana.crawford@case.edu

Affiliations Cleveland Institute for Computational Biology, Cleveland, Ohio, United States of America, Departments of Population and Quantitative Health Sciences and Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America

Competing Interests

SAP is employed by and receives salary from Genentech Inc, and JMJ is employed by and receives salary from Illumina, Inc. This does not alter our adherence with PLOS ONE policies on sharing data and materials. DCC is an academic editor of PLOS ONE. DCC is not involved in the review of this manuscript per journal policy.