About the Authors

Sara Oliviero

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft

s.oliviero@sheffield.ac.uk

Affiliations Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom, Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom

Mario Giorgi

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom, Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom, Certara QSP, Certara UK Ltd., Simcyp Division, Sheffield, United Kingdom

Peter J. Laud

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Statistical Services Unit, University of Sheffield, Sheffield, United Kingdom

Enrico Dall’Ara

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom, Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom, MRC Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), University of Sheffield, Sheffield, United Kingdom

Competing Interests

The commercial affiliation Certara QSP provided support in the form of salaries for authors [MG] during the revision of the manuscript. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.