About the Authors

Brody Mallard

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

David N. Leach

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliations Integria Healthcare, Eight Mile Plains, Queensland, Australia, National Institute of Complementary Medicine, Western Sydney University, Penrith, New South Wales, Australia

Hans Wohlmuth

Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

Affiliations Integria Healthcare, Eight Mile Plains, Queensland, Australia, National Institute of Complementary Medicine, Western Sydney University, Penrith, New South Wales, Australia, School of Chemistry & Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia

Joe Tiralongo

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

j.tiralongo@griffith.edu.au

Affiliation Institute for Glycomics, Griffith University, Gold Coast, Queensland, Australia

Competing Interests

This research was sponsored by Integria Healthcare (Australia) Pty Ltd., and was conducted collaboratively with DNL and HW who are employees of Integria Healthcare (Australia) Pty Ltd. DNL and HW quantified the glucan levels in the mushroom extracts, were involved in the preliminary cytokine expression study design, preliminary data analysis, editing and revising of the manuscript, and decision to publish. BM and JT are employees of Griffith University and designed and conducted the cytokine expression analysis as well as the synergy analysis. They acquired the cytokine expression data, analysed and interrupted the data, wrote, edited and revised the manuscript, and initiated the decision to publish. A patent application (International PCT Application No. PCT/AU2019/050295) based in part on these results has been filed by Integria Healthcare (Australia) Pty Ltd naming BM, DNL, HW and JT as inventors. DNL and HW are employees of Integria Healthcare (Australia) Pty Ltd, which is the sponsor of MediHerb® Mushroom Forte. We confirm that this does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.