About the Authors

Carl L. Manthey

Roles Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

‡ These authors are joint senior authors on this work.

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Beverley A. Moore

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

bamoore1786@gmail.com

Current address: BA Moore Pharmaceutical Consulting, LLC, Collegeville, Pennsylvania, United States of America

‡ These authors are joint senior authors on this work.

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Yanqing Chen

Roles Data curation, Formal analysis, Methodology, Software

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Matthew J. Loza

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Xiang Yao

Roles Data curation, Software, Writing – review & editing

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Hao Liu

Roles Data curation, Formal analysis, Software

Current address: Incyte, Wilmington, Delaware, United States of America

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Stanley M. Belkowski

Roles Methodology, Resources, Supervision

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Holly Raymond-Parks

Roles Data curation, Methodology, Software

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Paul J. Dunford

Roles Writing – review & editing

Current address: Provention Bio, Oldwick, New Jersey, United States of America

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Francisco Leon

Roles Writing – review & editing

Current address: Provention Bio, Oldwick, New Jersey, United States of America

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Jennifer E. Towne

Roles Project administration, Resources

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Scott E. Plevy

Roles Project administration, Resources, Supervision

Current address: Synlogic, Cambridge, Massachusetts, United States of America

Affiliation Janssen Research & Development, LLC, Pennsylvania, United States of America

Competing Interests

At the time of study conduct, all authors were salaried employees of Janssen R&D. Financial support for the study was solely provided by Janssen. All authors retain stock options with Janssen R&D. In addition, PJD and FL retain stock options with Provention Bio Inc. The authors would like to declare the following patents/patent applications associated with this research: CLM is listed as a co-inventor on Patent #’s 7,662,837 and 7,645,755 pertaining to JNJ40346527, however, all patents rights associated with this compound are solely owned by Janssen R&D and inventors do not receive financial remuneration. BAM is a part-time paid consultant for Provention Bio, but receives no remuneration associated with the development of the JNJ-40346527/PRV-6527. BAM receives additional salary support from BA Moore Pharmaceutical Consulting, HL from Incyte Corporation, PJD and FL from Provention Bio, and SEP from Synlogic Therapeutics. This does not alter our adherence to PLOS ONE policies on data integrity, data sharing and materials.