About the Authors

Yasmin Chau

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Fu-Shuang Li

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

Olesya Levsh

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Jing-Ke Weng

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

wengj@wi.mit.edu

Affiliations Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

Y.C., F.S.L., and J.K.W. have filed a provisional patent application titled “Analogs of the natural product icariin” on the icariin analogs described in this study (Inventors: Y.C., F.S.L., and J.K.W.; Filing number: 62/717,318). J.K.W. is a co-founder, a member of the Scientific Advisory Board, and a shareholder of DoubleRainbow Biosciences, which develops biotechnologies related to natural products. This does not alter our adherence to PLOS ONE policies on sharing data and materials.