About the Authors

Karen L. Hughes

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Karen.Hughes@liverpool.ac.uk

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Jamie J. Kirkham

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom, Centre for Biostatistics, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom

Mike Clarke

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Centre for Public Health, Institute of Clinical Sciences, Queen’s University Belfast, Royal Victoria Hospital, Belfast, United Kingdom

Paula R. Williamson

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: MC and PRW are members of the COMET Management Group. KLH and JJK declare that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.