About the Authors

Kathleen M. McAvoy

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Hameetha Rajamohamed Sait

Roles Data curation, Formal analysis, Methodology

Affiliation Biogen, Cambridge, MA, United States of America

Galina Marsh

Roles Data curation, Methodology, Visualization, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Michael Peterson

Roles Data curation, Formal analysis, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Taylor L. Reynolds

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Jake Gagnon

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Sarah Geisler

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Prescott Leach

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Biogen, Cambridge, MA, United States of America

Chris Roberts

Roles Data curation, Formal analysis, Methodology

Affiliation Biogen, Cambridge, MA, United States of America

Ellen Cahir-McFarland

Roles Conceptualization, Investigation, Supervision

Affiliation Biogen, Cambridge, MA, United States of America

Richard M. Ransohoff

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

Affiliation Department of Cell Biology, Harvard Medical School, Boston, MA, United States of America

Andrea Crotti

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

andrea.crotti@astellas.com

Current address: Astellas Innovation Management, Cambridge, MA, United States of America

Affiliation Biogen, Cambridge, MA, United States of America

Competing Interests

All the authors of the manuscript, with the exception of R.M.R., K.M.M., C.R. and A.C., are employees of Biogen. R.M.R., K.M.M., C.R. and A.C. are former employees of Biogen. R.M.R. is an employee of Third Rock Venture Capital, C.R. is an employee of the Genomic Institute of The Novartis Research Foundation. A.C. is an employee of Astellas Pharma. This does not alter our adherence to PLOS ONE policies on sharing data and materials.