About the Authors

Tatsuro Aikawa

Roles Data curation, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Kazunori Shimada

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

shimakaz@juntendo.ac.jp

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Katsumi Miyauchi

Roles Data curation, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tetsuro Miyazaki

Roles Formal analysis, Methodology, Supervision

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Eiryu Sai

Roles Data curation, Investigation, Methodology, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Shohei Ouchi

Roles Investigation, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tomoyasu Kadoguchi

Roles Investigation, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Mitsuhiro Kunimoto

Roles Investigation, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Yusuke Joki

Roles Project administration, Supervision

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Tomotaka Dohi

Roles Investigation, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Shinya Okazaki

Roles Investigation, Methodology, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Kikuo Isoda

Roles Investigation, Methodology, Project administration

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Koji Ohashi

Roles Data curation, Formal analysis, Investigation, Project administration

Affiliation Department of Molecular Medicine and Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Toyoaki Murohara

Roles Formal analysis, Investigation, Supervision

Affiliation Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Noriyuki Ouchi

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Department of Molecular Medicine and Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Hiroyuki Daida

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan

Competing Interests

K. Shimada has received lecture fees from Daiichi-Sankyo Pharmaceutical Company Ltd., and Takeda Pharmaceutical Company Ltd. Department of Molecular Medicine and Cardiology was endowed by Kowa Pharmaceutical Co Ltd (to N.O. and K.O.). H. Daida has received remuneration for lectures from Amgen Astellas Biopharma K.K., Astellas Pharma Inc., AstraZeneca Pharma Ltd., GlaxoSmithKline K.K., Sanofi K.K., Shionogi, Daiichi-Sankyo Pharmaceutical Company Ltd., Takeda Pharmaceutical Company Ltd., Terumo Corporation, Medtronic plc., Boehringer Ingelheim GmbH., Bayer AG., and MSD K.K., trust research and joint research funds from Kowa Pharmaceutical Company Ltd., Daiichi-Sankyo Company Ltd., Canon Medical Systems Corporation, Nihon Medi-Physics Company Ltd., Kaken Pharmaceutical Company Ltd., Kirin Holdings Company Ltd., Philips Respironics Ltd., Sanwa Kagaku Kenkyusho Company Ltd., and St. Jude Medical Japan Company Ltd., and scholarship fund from Astellas Pharma Inc., Abbott Laboratories, Otsuka Pharmaceutical Company Ltd., Sanofi K.K., Shionogi & Company Ltd., Sumitomo Dainippon Pharmaceutical Company Ltd., Boehringer Ingelheim GmbH., Bayer AG., Teijin Ltd., Daiichi-Sankyo Company Ltd., Takeda Pharmaceutical Company Ltd., MSD K.K., Tanabe Mitsubishi Pfizer Pharmaceutical Company Ltd., Philips Respironics Ltd., Bristol-Myers Squibb Company Ltd., Boston Scientific Ltd., St. Jude Medical Japan Company Ltd., and Actelion Pharmaceuticals Japan Ltd. He has been in affiliation with some endowed departments including VitalAire Japan Company K.K., Philips Respironics Ltd., Fukuda Denshi Company Ltd., ResMed Ltd. The remaining authors report no conflict of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.