About the Authors

Friederike L. Jayes

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Friederike.Jayes@duke.edu

Affiliations Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pathology, Duke University School of Medicine, Durham, North Carolina, United States of America

Betty Liu

Roles Data curation, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

Current address: Cobalt Robotics, San Mateo, California, United States of America

Affiliation Department of Orthopedics, Duke University School of Medicine and Duke University School of Engineering, Durham, North Carolina, United States of America

Liping Feng

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States of America

Nydea Aviles-Espinoza

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Current address: Scientific Laboratory Division, New Mexico Department of Health, Albuquerque, New Mexico, United States of America

Affiliation Bone and Matrix Biology in Development and Disease, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America

Sergey Leikin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Bone and Matrix Biology in Development and Disease, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, United States of America

Phyllis C. Leppert

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Pathology, Duke University School of Medicine, Durham, North Carolina, United States of America

Competing Interests

We have the following interests: BioSpecifics Technologies Corporation (BTC) provided partial funding for the work presented here. None of the authors are employed by this company. None of the authors own stock in the company. Two and a half years ago PCL presented findings of a study, now published [Jayes, 2016] to the Board of Directors of the company. PCL is listed on a patent (Phyllis Leppert, Thomas Wegman, Darlene Taylor: Treatment method and product for uterine fibroids using purified collagenase US9744138B2). The proceeds, if any, of this patent are assigned to BTC and a portion of the profit assigned to Duke University. Our submitted manuscript is unrelated to the patent. Our manuscript does not involve the use of collagenase as a treatment. Both PCL and FLJ are involved in a phase I clinical trial of collagenase for fibroid treatment being conducted by James Segars, PI at Johns Hopkins University. There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.