About the Authors

Kohsuke Shirakawa

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiology, Keio University School of Medicine, Tokyo, Japan

Wataru Yano

Roles Investigation, Methodology, Writing – review & editing

Affiliation Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan

Keisuke Inoue

Roles Investigation, Methodology, Writing – review & editing

Affiliation Tokyo New Drug Research Laboratories, Kowa Company, Ltd., Tokyo, Japan

Yoshinori Katsumata

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Cardiology, Keio University School of Medicine, Tokyo, Japan

Jin Endo

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Cardiology, Keio University School of Medicine, Tokyo, Japan

Motoaki Sano

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

msano@a8.keio.jp

Affiliation Department of Cardiology, Keio University School of Medicine, Tokyo, Japan

Competing Interests

The affiliation of the authors W.Y. and K.I. with Kowa Company, Ltd. does not alter their adherence to all the PLOS ONE policies on sharing data and materials.