About the Authors

Emi Kurimoto

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Masato Nakashima

Roles Conceptualization, Data curation, Formal analysis, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Haruhide Kimura

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Motohisa Suzuki

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

motohisa.suzuki@takeda.com

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

Competing Interests

We have the following interests. Emi Kurimoto, Masato Nakashima, Haruhide Kimura and Motohisa Suzuki are employed by Takeda Pharmaceutical Company Limited. TAK-071 is currently being clinically evaluated, and there is a patent: WO/2015/163485A1. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.