About the Authors

Zhiyuan Ma

Contributed equally to this work with: Zhiyuan Ma, Ping Wang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

zhiyuan.ma@duke.edu (ZM); ruobing.wang@duke.edu (RW); koroushkhalighi@gmail.com (KK)

Affiliations Easton Cardiovascular Associates, Easton, PA, United States of America, Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, United States of America

Ping Wang

Contributed equally to this work with: Zhiyuan Ma, Ping Wang

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Easton Cardiovascular Associates, Easton, PA, United States of America

Zehui Gao

Roles Methodology

Affiliation Department of Mathematics and Statistics, San Diego State University, La Mesa, CA, United States of America

Ruobing Wang

Roles Methodology, Writing – review & editing

zhiyuan.ma@duke.edu (ZM); ruobing.wang@duke.edu (RW); koroushkhalighi@gmail.com (KK)

Affiliations Department of Chemistry and Social Science Research Institute, Duke University, Durham, NC, United States of America, Science Center of Opera Solutions LLC, San Diego, CA, United States of America

Koroush Khalighi

Roles Investigation, Resources, Supervision, Writing – review & editing

zhiyuan.ma@duke.edu (ZM); ruobing.wang@duke.edu (RW); koroushkhalighi@gmail.com (KK)

Affiliations Easton Cardiovascular Associates, Easton, PA, United States of America, Division of Cardiology, Department of Medicine, Easton Hospital, Easton, PA, United States of America, Drexel University College of Medicine, Philadelphia, PA, United States of America

Competing Interests

This commercial affiliation [Science Center of Opera Solutions LLC for R.W.] does not alter our adherence to PLOS ONE policies on sharing data and materials.