Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells

Valentin-Florian Rauca; Emilia Licarete; Lavinia Luput; Alina Sesarman; Laura Patras; Paul Bulzu; Elena Rakosy-Tican; Manuela Banciu

doi:10.1371/journal.pone.0202827

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Open Access

Peer-reviewed

Research Article

Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells

Valentin-Florian Rauca,

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Emilia Licarete,

Roles Investigation, Methodology

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Lavinia Luput,

Roles Investigation, Methodology

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Alina Sesarman,

Roles Methodology

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Laura Patras,

Roles Methodology

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Paul Bulzu,

Roles Visualization

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Elena Rakosy-Tican,

Roles Validation

Affiliation Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania
⨯
Manuela Banciu

Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft

* E-mail: manuela.banciu@ubbcluj.ro

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania

http://orcid.org/0000-0003-2556-4008

⨯

Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells

Valentin-Florian Rauca,
Emilia Licarete,
Lavinia Luput,
Alina Sesarman,
Laura Patras,
Paul Bulzu,
Elena Rakosy-Tican,
Manuela Banciu

Published: August 23, 2018
https://doi.org/10.1371/journal.pone.0202827

About the Authors

Valentin-Florian Rauca

Roles Conceptualization, Investigation, Methodology, Writing – original draft

Affiliations Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania, Molecular Biology Centre, Institute for Interdisciplinary Research in Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Romania

Emilia Licarete

Roles Investigation, Methodology

Lavinia Luput

Roles Investigation, Methodology

Alina Sesarman

Roles Methodology

Laura Patras

Roles Methodology

Paul Bulzu

Roles Visualization

Elena Rakosy-Tican

Roles Validation

Affiliation Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, Cluj-Napoca, Romania

Manuela Banciu

Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft

* E-mail: manuela.banciu@ubbcluj.ro

http://orcid.org/0000-0003-2556-4008

Competing Interests

The authors have declared that no competing interests exist.

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Cancer treatment
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Melanoma cells
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Antioxidant therapy
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Macrophages
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Skin tumors
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