About the Authors

Lorna M. Gibson

Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Clinical Radiology, New Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom

Francesca M. Chappell

Roles Formal analysis, Methodology, Supervision, Validation, Writing – review & editing

Affiliation Centre for Clinical Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom

David Summers

Roles Data curation, Writing – review & editing

Affiliation Department of Neuroradiology, Western General Hospital, Edinburgh, United Kingdom

Donald A. Collie

Roles Investigation, Writing – review & editing

Affiliation Fife Acute Hospitals NHS Trust, Kirkcaldy, United Kingdom

Robin Sellar

Roles Investigation, Writing – review & editing

Affiliation Centre for Clinical Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom

Jonathan Best

Roles Methodology, Writing – review & editing

Affiliation Department of Neuroradiology, Western General Hospital, Edinburgh, United Kingdom

Richard Knight

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Centre for Clinical Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom, National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Western General Hospital, Edinburgh, United Kingdom

James W. Ironside

Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

Affiliations Centre for Clinical Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom, National Creutzfeldt-Jakob Disease Research and Surveillance Unit, Western General Hospital, Edinburgh, United Kingdom

Joanna M. Wardlaw

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Joanna.wardlaw@ed.ac.uk

Affiliations Centre for Clinical Brain Sciences and UK Dementia Research Institute at the University of Edinburgh, Edinburgh, United Kingdom, Department of Neuroradiology, Western General Hospital, Edinburgh, United Kingdom, Brain Research Imaging Centre, Western General Hospital, Edinburgh, United Kingdom

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: Dr. Gibson, Dr. Chappell, Dr. Summers, Dr. Collie, Professor Sellar, Professor Best and Professor Knight have nothing to disclose. Professor Ironside reports grants from Department of Health Policy Research Programme/Scottish Government, grants from Medical Research Council, personal fees from Piramal, personal fees from Covance, outside the submitted work. Professor Wardlaw reports grants from Boehringer Ingelheim, grants from Scottish Funding Council, grants from MRC, grants from Novartis, during the conduct of the study; grants from EU, grants from Wellcome Trust, grants from MRC, grants from BHF, grants from EPSRC, grants from CSO, other from GlaxoSmithKline, outside the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.