About the Authors

Ann-Sofie Sandinge

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

ann-sofie.sandinge@astrazeneca.com

Affiliation Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden

Annika Janefeldt

Roles Conceptualization, Data curation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden

Susanne Pehrsson

Roles Data curation, Formal analysis, Investigation, Software, Validation, Writing – review & editing

Affiliation Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden

Sven Nylander

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Cardiovascular, Renal and Metabolism, Innovative Medicines and Early Development Biotech Unit, AstraZeneca, Gothenburg, Sweden

Competing Interests

Authors with affiliation AstraZeneca are employed by AstraZeneca. The competing interest declared did not alter our adherence to PLOS ONE policies on sharing data and materials.