About the Authors

Leonardo De Luca

Roles Conceptualization, Writing – original draft, Writing – review & editing

leo.deluca@libero.it

Affiliation Division of Cardiology, S. Giovanni Evangelista Hospital, Tivoli (Roma), Italy

Pier Luigi Temporelli

Roles Writing – original draft

Affiliation Division of Cardiology, Istituti Clinici Scientifici Maugeri, IRCCS, Veruno (Novara), Italy

Donata Lucci

Roles Data curation

Affiliation ANMCO Research Center, Firenze, Italy

Furio Colivicchi

Roles Writing – review & editing

Affiliation Division of Cardiology, S. Filippo Neri Hospital, Roma, Italy

Paolo Calabrò

Roles Investigation, Writing – review & editing

Affiliation Department of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy

Carmine Riccio

Roles Writing – review & editing

Affiliation Department of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy

Antonio Amico

Roles Investigation

Affiliation Division of Cardiology, S. Giuseppe Hospital, Copertino (Lecce), Italy

Franco Mascia

Roles Writing – review & editing

Affiliation Department of Cardiology, Azienda Ospedaliera Sant'Anna e San Sebastiano, Caserta, Italy

Emanuele Proia

Roles Investigation

Affiliation Division of Cardiology Ave Gratia Plena Hospital, Piedimonte Matese (Caserta) Italy

Andrea Di Lenarda

Roles Writing – review & editing

Affiliation Cardiology, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy

Michele Massimo Gulizia

Roles Conceptualization, Writing – review & editing

Affiliation Division of Cardiology, Garibaldi-Nesima Hospital, Catania, Italy

on behalf of the START Investigators

Membership of the author group is provided in the Acknowledgments.

Competing Interests

Dr. De Luca and Dr. Temporelli report personal fees from Menarini, outside the submitted work; Lucci is an employee of Heart Care Foundation, which conducted the study with an unresctricted grant of research from Menarini, Italy. These commenrcial fundings do not alter our adherence to PLOS ONE policies on sharing data and materials. All other authors have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.