About the Authors

Pik Eu Chang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

jason.chang@singhealth.com.sg

Affiliations Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore

George Boon Bee Goh

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore

Wei Qiang Leow

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliations Duke-NUS Medical School, Singapore, Department of Anatomical Pathology, Singapore General Hospital, Singapore

Liang Shen

Roles Formal analysis, Methodology, Validation

Affiliation Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Kiat Hon Lim

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Validation, Writing – review & editing

Affiliations Duke-NUS Medical School, Singapore, Department of Anatomical Pathology, Singapore General Hospital, Singapore

Chee Kiat Tan

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, Duke-NUS Medical School, Singapore

Competing Interests

We have the following interests: This research work was supported by a project collaboration agreement with Diagnostics Development (DxD) Hub of Exploit Technologies Pte. Ltd., Singapore, and HistoIndex Pte. Ltd., Singapore. Collaborating parties invested contributions to enable completion of the research. HistoIndex Pte. Ltd. provided the imaging hardware and assisted in the development of the algorithm. Diagnostics Development Hub provided funding to support retrieval of the archived biopsy specimens, collation of clinical data and development and validation of the algorithm. Employees of HistoIndex Pte. Ltd. assisted in the description of the study methodology, provision of images and assisted in data analysis. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.