About the Authors

Menaka Pai

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

mpai@mcmaster.ca

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Hamilton Regional Laboratory Medicine Program, Hamilton, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

Neill K. J. Adhikari

Roles Conceptualization, Writing – review & editing

Affiliations Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

Marlies Ostermann

Roles Conceptualization, Writing – review & editing

Affiliation Department of Critical Care, Guys and St Thomas Hospital, London, England

Diane Heels-Ansdell

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

James D. Douketis

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

Yoanna Skrobik

Roles Writing – review & editing

Affiliation Department of Medicine, Hôpital Maisonneuve Rosemont, Montréal, Canada

Ismael Qushmaq

Roles Conceptualization, Writing – review & editing

Affiliation Department of Medicine, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia

Maureen Meade

Roles Conceptualization, Writing – review & editing

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

Gordon Guyatt

Roles Conceptualization, Writing – review & editing

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

William Geerts

Roles Conceptualization, Writing – review & editing

Affiliation Department of Medicine, University of Toronto, Toronto, Canada

Michael W. Walsh

Roles Conceptualization, Writing – review & editing

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

Mark A. Crowther

Roles Conceptualization, Writing – review & editing

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Hamilton Regional Laboratory Medicine Program, Hamilton, Canada, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

Jan O. Friedrich

Roles Conceptualization, Writing – review & editing

Affiliations Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada, Department of Medicine, University of Toronto, Toronto, Canada

Lisa Burry

Roles Conceptualization, Writing – review & editing

Affiliation Mount Sinai Hospital, Toronto, Canada

Rinaldo Bellomo

Roles Conceptualization, Writing – review & editing

Affiliation Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Australia

Nilton Brandão da Silva

Roles Conceptualization, Writing – review & editing

Affiliation Moinhos de Vento Hospital, Porto Alegre, Brazil

Rubens Costa Filho

Roles Conceptualization, Writing – review & editing

Affiliation Pró Cardíaco Hospital, PROCEP, Rio de Janeiro, Brazil

Michael J. Cox

Roles Conceptualization, Writing – review & editing

Affiliation St. John's Mercy Medical Center, St. Louis, Missouri, United States of America

Suzana Alves Silva

Roles Conceptualization, Writing – review & editing

Affiliation Pró Cardíaco Hospital, PROCEP, Rio de Janeiro, Brazil

Deborah J. Cook

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Medicine, McMaster University, Hamilton, Canada, Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

on behalf of the PROTECT (Prophylaxis for Thromboembolism in Critical Care Trial) Investigators

Membership of the PROTECT Investigators is provided in the Acknowledgments.

Competing Interests

This study received support from Pfizer Canada, which provided dalteparin for Canadian centers, and Eisai, Inc, which provided dalteparin for centers in the United States. Neither group played a role in the design, conduct, analysis, interpretation or write-up of this trial. The authors have no other relevant declarations relating to employment, consultancy, patents, products in development, or marketed products. The competing interests declared here do not alter our adherence to PLOS ONE policies on sharing data and materials.