About the Authors

Shenda Gu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of America

Worapol Ngamcherdtrakul

Roles Funding acquisition, Methodology, Resources, Writing – review & editing

Affiliations Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of America, PDX Pharmaceuticals, LLC, Portland, Oregon, United States of America

Moataz Reda

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of America

Zhi Hu

Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of America

Joe W. Gray

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of America

Wassana Yantasee

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

yantasee@ohsu.edu

Affiliations Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, United States of America, PDX Pharmaceuticals, LLC, Portland, Oregon, United States of America

Competing Interests

The authors of this manuscript and their institution have the following competing interests: Oregon Health & Science University, W.N., W.Y., and J.W.G. have a significant financial interest in PDX Pharmaceuticals, LLC, a company that may have a commercial interest in the results of this research and technology. This potential personal and institutional conflict of interest has been reviewed and managed by Oregon Health & Science University. This commercial affiliation does not alter our adherence to PLOS ONE policies on sharing data and materials.