About the Authors

Roi Treister

Roles Investigation, Supervision, Writing – original draft, Writing – review & editing

tresiter.roi@gmail.com

Affiliations Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel, Analgesic Solutions, Natick, Massachusetts, United States of America

Oluwadolapo D. Lawal

Roles Investigation, Methodology

Affiliation Analgesic Solutions, Natick, Massachusetts, United States of America

Jonathan D. Shecter

Roles Investigation

Affiliation Analgesic Solutions, Natick, Massachusetts, United States of America

Nevil Khurana

Roles Investigation, Project administration

Affiliation Analgesic Solutions, Natick, Massachusetts, United States of America

John Bothmer

Roles Conceptualization, Funding acquisition

Affiliation Grunenthal GmbH, Aachen, Germany

Mark Field

Roles Conceptualization, Funding acquisition

Affiliation Grunenthal GmbH, Aachen, Germany

Steven E. Harte

Roles Methodology

Affiliation Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America

Grant H. Kruger

Roles Conceptualization, Methodology

Affiliations Chronic Pain and Fatigue Research Center, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

Nathaniel P. Katz

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliations Analgesic Solutions, Natick, Massachusetts, United States of America, Department of Anaesthesiology and Perioperative Medicine, Tufts University School of Medicine, Boston, Massachusetts, United States of America

Competing Interests

SEH has received research funding from Cerephex, Eli Lily, Forest Laboratories, and Merck; and served as a consultant for Pfizer, Analgesic Solutions, Aptinyx, and deCode Genetics. He is also co-inventor of the MAST pain testing device and a member of Arbor Medical Innovations, LLC (Ann Arbor, MI). GHK is a co-inventor of the MAST and a member of Arbor Medical Innovations (AMI), LLC, which assisted in providing the MAST systems used as part of this study. He has also served as a consultant to Analgesic Solutions and deCode Genetics. NPK is the CEO of Analgesic Solutions, a clinical research and consulting firm with many clients throughout the pharmaceutical industry. RT and OL are employees of Analgesic Solutions. NK and JDS are former employees of Analgesic Solutions. JB and MF are employees of Grunenthal. This does not alter our adherence to PLOS ONE policies on sharing data and materials.