About the Authors

Florian Kamm

Contributed equally to this work with: Florian Kamm, Ulrike Strauch

Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

Ulrike Strauch

Contributed equally to this work with: Florian Kamm, Ulrike Strauch

Roles Data curation, Methodology, Supervision, Writing – original draft

Affiliation Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

Frauke Degenhardt

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany

Rocio Lopez

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, United States of America

Claudia Kunst

Roles Conceptualization, Investigation, Writing – review & editing

Affiliation Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

Gerhard Rogler

Roles Conceptualization, Investigation, Resources, Writing – review & editing

Affiliations Department of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland, Zurich Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland

Andre Franke

Roles Conceptualization, Resources, Writing – review & editing

Affiliation Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany

Frank Klebl

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation Department of Internal Medicine I, University of Regensburg, Regensburg, Germany

Florian Rieders

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

riederf@ccf.org

Affiliations Department of Internal Medicine I, University of Regensburg, Regensburg, Germany, Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, United States of America

Competing Interests

F.R. is on the advisory board and/or speakers’ bureau of AbbVie, UCB and consultant to UCB, Celgene, Pliant, Roche, Sansung and Thetis. G.R. has consulted to Abbvie, Augurix, Boehringer, Calypso, FALK, Ferring, Fisher, Genentech, Essex/MSD, Novartis, Pfizer, Phadia, Roche, UCB, Takeda, Tillots, Vifor, Vital Solutions and Zeller; Gerhard Rogler has received speaker's honoraria from Astra Zeneca, Abbott, Abbvie, FALK, MSD, Phadia, Tillots, UCB, and Vifor; Gerhard Rogler has received educational grants and research grants from Abbot, Abbvie, Ardeypharm, Augurix, Calypso, Essex/MSD, FALK, Flamentera, Novartis, Roche, Takeda, Tillots, UCB and Zeller. This does not alter our adherence to PLOS ONE policies on sharing data and materials.