About the Authors

Tomoe Tsuboi

Contributed equally to this work with: Tomoe Tsuboi, Morihiko Maeda

Roles Investigation, Writing – original draft

Affiliations Department of Geriatrics, Nagoya University Graduate School of Medicine School of Health Sciences, Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan, Chubu University Graduate School of Bioscience and Biotechnology, Matsumoto-cho, Kasugai, Aichi, Japan

Morihiko Maeda

Contributed equally to this work with: Tomoe Tsuboi, Morihiko Maeda

Roles Data curation, Investigation

Affiliation Department of Geriatrics, Nagoya University Graduate School of Medicine School of Health Sciences, Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan

Toshio Hayashi

Roles Project administration

hayashi@med.nagoya-u.ac.jp

Affiliation Department of Geriatrics, Nagoya University Graduate School of Medicine School of Health Sciences, Daiko-Minami, Higashi-ku, Nagoya, Aichi, Japan

Competing Interests

The authors received funding from KYOWA HAKKO BIO CO., LTD, a commercial company, for this study. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.