About the Authors

Kengo Suzuki

Roles Supervision, Writing – original draft

Affiliation Euglena Co., Ltd., Shiba, Minato-ku, Tokyo, Japan

Ayaka Nakashima

Roles Investigation, Project administration, Writing – original draft

Affiliation Euglena Co., Ltd., Shiba, Minato-ku, Tokyo, Japan

Masaharu Igarashi

Roles Formal analysis

Affiliation New Drug Research Center, Inc., Toiso, Eniwa, Hokkaido, Japan

Keita Saito

Roles Formal analysis, Writing – original draft

Affiliation New Drug Research Center, Inc., Toiso, Eniwa, Hokkaido, Japan

Makoto Konno

Roles Investigation, Writing – original draft

Affiliation New Drug Research Center, Inc., Toiso, Eniwa, Hokkaido, Japan

Noriyuki Yamazaki

Roles Investigation, Writing – original draft

Affiliation New Drug Research Center, Inc., Toiso, Eniwa, Hokkaido, Japan

Hiroaki Takimoto

Roles Supervision

takimoto@sci.kitasato-u.ac.jp

Affiliation Kitasato University, School of Science, Department of Biosciences, Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan

Competing Interests

Dr. Kengo Suzuki and Ms. Ayaka Nakashima are employees of euglena Co., Ltd., and Mr. Masaharu Igarashi, Mr. Keitai Saito, Mr. Makoto Konno and Mr. Noriyuki Yamazaki are employees of New Drug Research Center, Inc. The results presented in this manuscript are patent pending in Japan. There are no other patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.