About the Authors

Katherine Davis

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Sarah L. Gorst

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – review & editing

sgorst@liverpool.ac.uk

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Nicola Harman

Roles Investigation, Methodology, Writing – review & editing

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Valerie Smith

Roles Investigation, Methodology, Writing – review & editing

Affiliation School of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland

Elizabeth Gargon

Roles Conceptualization, Methodology, Writing – review & editing

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Douglas G. Altman

Roles Writing – review & editing

Affiliation Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom

Jane M. Blazeby

Roles Writing – review & editing

Affiliation MRC ConDuCT II Hub for Trials Methodology Research, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom

Mike Clarke

Roles Writing – review & editing

Affiliation Centre for Public Health, Queen’s University Belfast, Belfast, United Kingdom

Sean Tunis

Roles Writing – review & editing

Affiliation Center for Medical Technology Policy (CMTP), World Trade Center Baltimore, Baltimore, MD, United States of America

Paula R. Williamson

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation MRC North West Hub for Trials Methodology Research, Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom

Competing Interests

DGA, JMB, MC, ST and PRW are members of the COMET Management Group and coapplicants on grants to support COMET and related work. KD and EG are the COMET Project Co-ordinators. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.