About the Authors

Dariush Mozaffarian

Roles Conceptualization, Data curation, Methodology, Project administration, Writing – original draft, Writing – review & editing

dariush.mozaffarian@tufts.edu

Affiliation Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA, United States of America

Hassan S Dashti

Roles Methodology, Resources, Writing – review & editing

Affiliations Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA, United States of America, Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States of America

Mary K Wojczynski

Roles Formal analysis

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States of America

Audrey Y Chu

Roles Methodology, Resources, Writing – review & editing

Affiliation Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America

Jennifer A Nettleton

Roles Formal analysis

Affiliation Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America

Satu Männistö

Roles Methodology, Resources, Writing – review & editing

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Kati Kristiansson

Roles Formal analysis

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Mägi Reedik

Roles Methodology, Resources, Writing – review & editing

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Jari Lahti

Roles Formal analysis

Affiliations Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland

Denise K Houston

Roles Methodology, Resources, Writing – review & editing

Affiliation Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC, United States of America

Marilyn C Cornelis

Roles Formal analysis

Affiliation Department of Nutrition, Harvard School of Public Health, Boston, MA, United States of America

Frank J. A van Rooij

Roles Formal analysis

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

Maria Dimitriou

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Dietetics and Nutrition, Harokopio University, Athens, Greece

Stavroula Kanoni

Roles Formal analysis

Affiliation William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

Vera Mikkilä

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Food and Environmental Sciences, University of Helsinki, Finland, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

Lyn M Steffen

Roles Methodology, Resources, Writing – review & editing

Affiliation Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, United States of America

Marcia C de Oliveira Otto

Roles Methodology, Resources, Writing – review & editing

Affiliation Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, United States of America

Lu Qi

Roles Methodology, Resources, Writing – review & editing

Affiliation Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

Bruce Psaty

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, United States of America

Luc Djousse

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Medicine, Harvard Medical School, and Division of Aging Brigham and Women's Hospital, Boston, MA, United States of America

Jerome I Rotter

Roles Methodology, Resources, Writing – review & editing

Affiliation Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles, CA, United States of America

Kennet Harald

Roles Methodology, Resources, Writing – review & editing

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Markus Perola

Roles Methodology, Resources, Writing – review & editing

Affiliations National Institute for Health and Welfare, Helsinki, Finland, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, University of Tartu, Estonian Genome Center, Tartu, Estonia

Harri Rissanen

Roles Methodology, Resources, Writing – review & editing

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Antti Jula

Roles Methodology, Resources, Writing – review & editing

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Fischer Krista

Roles Methodology, Resources, Writing – review & editing

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Evelin Mihailov

Roles Methodology, Resources, Writing – review & editing

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Mary F Feitosa

Roles Formal analysis

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States of America

Julius S Ngwa

Roles Formal analysis

Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, Division of Cardiovascular Medicine, Howard University College of Medicine, Washington DC, United States of America

Luting Xue

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America

Paul F Jacques

Roles Methodology, Resources, Writing – review & editing

Affiliations Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA, United States of America, Nutritional Epidemiology Program, USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, United States of America

Mia-Maria Perälä

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

Aarno Palotie

Roles Methodology, Resources, Writing – review & editing

Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

Yongmei Liu

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC, United States of America

Nike A Nalls

Roles Methodology, Resources, Writing – review & editing

Affiliation Laboratory of Neurogenetics, National Institute of Aging, Bethesda, MD, United States of America

Luigi Ferrucci

Roles Methodology, Resources, Writing – review & editing

Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America

Dena Hernandez

Roles Methodology, Resources, Writing – review & editing

Affiliation Laboratory of Neurogenetics, National Institute of Aging, Bethesda, MD, United States of America

Ani Manichaikul

Roles Formal analysis

Affiliation Center for Public Health Genomics and Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States of America

Michael Y Tsai

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States of America

Jessica C Kiefte-de Jong

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Leiden University College, The Hague, The Netherlands

Albert Hofman

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

André G Uitterlinden

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

Loukianos Rallidis

Roles Methodology, Resources, Writing – review & editing

Affiliation Second Department of Cardiology, University General Hospital Attikon, Athens, Greece

Paul M Ridker

Roles Methodology, Resources, Writing – review & editing

Affiliations National Institute for Health and Welfare, Helsinki, Finland, Harvard Medical School, Boston MA, United States of America

Lynda M Rose

Roles Methodology, Resources, Writing – review & editing

Affiliation Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America

Julie E Buring

Roles Methodology, Resources, Writing – review & editing

Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America, Harvard Medical School, Boston MA, United States of America

Terho Lehtimäki

Roles Formal analysis

Affiliation Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere, Finland

Mika Kähönen

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

Jorma Viikari

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland

Rozenn Lemaitre

Roles Formal analysis

Affiliation Department of Medicine, University of Washington, Seattle, WA, United States of America

Veikko Salomaa

Roles Methodology, Resources, Writing – review & editing

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Paul Knekt

Roles Methodology, Resources, Writing – review & editing

Affiliation National Institute for Health and Welfare, Helsinki, Finland

Andres Metspalu

Roles Methodology, Resources, Writing – review & editing

Affiliation Estonian Genome Center, University of Tartu, Tartu, Estonia

Ingrid B Borecki

Roles Methodology, Resources, Writing – review & editing

Affiliation Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States of America

L. Adrienne Cupples

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, NHLBI Framingham Heart Study, Framingham, MA, United States of America

Johan G Eriksson

Roles Methodology, Resources, Writing – review & editing

Affiliations National Institute for Health and Welfare, Helsinki, Finland, Department of General Practice and Primary health Care, University of Helsinki, Helsinki, Finland, Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland

Stephen B Kritchevsky

Roles Methodology, Resources, Writing – review & editing

Affiliation Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC, United States of America

Stefania Bandinelli

Roles Methodology, Resources, Writing – review & editing

Affiliation Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze, Florence, Italy

David Siscovick

Roles Methodology, Resources, Writing – review & editing

Affiliation New York Academy of Medicine, New York, NY, United States of America

Oscar H Franco

Roles Methodology, Resources, Writing – review & editing

Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands, Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

Panos Deloukas

Roles Methodology, Resources, Writing – review & editing

Affiliations William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorder, King Abdulaziz University, Jeddah, Saudi Arabia

George Dedoussis

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Dietetics and Nutrition, Harokopio University, Athens, Greece

Daniel I Chasman

Roles Methodology, Resources, Writing – review & editing

Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America, Harvard Medical School, Boston MA, United States of America

Olli Raitakari

Roles Methodology, Resources, Writing – review & editing

Affiliations Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

Toshiko Tanaka

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America

Competing Interests

Luc Djousse reports receiving investigator-initiated grants (omega-3 fatty acid studies) from NIH and Amarin Pharma, Inc. Currently serving as ad hoc consultant for Amarin Pharma, Inc. Bruce Psaty reports serving on the DSMB of a clinical trial for a device funded by the manufacturer (Zoll LifeCor) and on the Steering Committee for the Yale Open Data Access Project funded by Johnson & Johnson." Paul Ridker has received research grant funds from AstraZeneca, a manufacturer of a prescription fish oil product. Oscar Franco works in ErasmusAGE, a center for aging research across the life course funded by Nestlé Nutrition (Nestec Ltd.); Metagenics Inc.; and AXA. Nestlé Nutrition (Nestec Ltd.); Metagenics Inc.; and AXA had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review or approval of the manuscript. Dr. Mozaffarian reports reports ad hoc honoraria or consulting from Bunge, Haas Avocado Board, Nutrition Impact, Amarin, Astra Zeneca, Boston Heart Diagnostics, GOED, and Life Sciences Research Organization; and scientific advisory boards, Unilever North America and Elysium Health.Harvard University holds a patent, listing Dr. Mozaffarian as one of three co-inventors, for use of trans-palmitoleic acid to prevent and treat insulin resistance, type 2 diabetes, and related conditions. All other authors report no conflicts of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.