About the Authors

Patrick Laurén

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

patrick.lauren@helsinki.fi

Affiliation Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Petter Somersalo

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation

Affiliation Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Irina Pitkänen

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Engineering Design and Production, School of Engineering, Aalto University, Espoo, Finland

Yan-Ru Lou

Roles Conceptualization, Supervision, Validation, Writing – review & editing

Affiliation Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Arto Urtti

Roles Conceptualization, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliations Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Jouni Partanen

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Engineering Design and Production, School of Engineering, Aalto University, Espoo, Finland

Jukka Seppälä

Roles Conceptualization, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Engineering Design and Production, School of Engineering, Aalto University, Espoo, Finland

Mari Madetoja

Roles Formal analysis, Investigation, Resources, Visualization

Affiliation Made Consulting, Turku, Finland

Timo Laaksonen

Roles Formal analysis, Resources, Supervision, Validation, Writing – review & editing

Affiliations Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland, Department of Chemistry and Bioengineering, Tampere University of Technology, Tampere, Finland

Antti Mäkitie

Roles Conceptualization, Formal analysis, Validation, Visualization, Writing – review & editing

Affiliation Department of Otorhinolaryngology—Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Marjo Yliperttula

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

Affiliation Division of Pharmaceutical Biosciences, Centre for Drug Research, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland

Competing Interests

All authors of this manuscript declare that no competing interests exist, and concerning affiliations (participating Universities and Made Consulting), this does not alter our adherence to PLOS ONE policies on sharing data and materials.