Addressing the challenge of high-priced prescription drugs in the era of precision medicine: A systematic review of drug life cycles, therapeutic drug markets and regulatory frameworks

Toon van der Gronde; Carin A. Uyl-de Groot; Toine Pieters

doi:10.1371/journal.pone.0182613

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Addressing the challenge of high-priced prescription drugs in the era of precision medicine: A systematic review of drug life cycles, therapeutic drug markets and regulatory frameworks

Toon van der Gronde,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands
⨯
Carin A. Uyl-de Groot,

Roles Writing – original draft, Writing – review & editing

Affiliation Institute for Medical Technology Assessment, Department of Health Policy & Management, Erasmus University, Rotterdam, the Netherlands
⨯
Toine Pieters

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: t.pieters@uu.nl

Affiliation Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands

http://orcid.org/0000-0002-8156-8436

⨯

Addressing the challenge of high-priced prescription drugs in the era of precision medicine: A systematic review of drug life cycles, therapeutic drug markets and regulatory frameworks

Toon van der Gronde,
Carin A. Uyl-de Groot,
Toine Pieters

Published: August 16, 2017
https://doi.org/10.1371/journal.pone.0182613

About the Authors

Toon van der Gronde

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands

Carin A. Uyl-de Groot

Roles Writing – original draft, Writing – review & editing

Affiliation Institute for Medical Technology Assessment, Department of Health Policy & Management, Erasmus University, Rotterdam, the Netherlands

Toine Pieters

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: t.pieters@uu.nl

Affiliation Department of Pharmaceutical Sciences, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands

http://orcid.org/0000-0002-8156-8436

Competing Interests

The authors have declared that no competing interests exist.

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Drug prices
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Drug research and development
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Drug regulation
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Physicians
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Drug therapy
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Life cycles
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Drug adherence
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Finance
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