About the Authors

Takeshi Fukuhara

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

tfukuha@juntendo.ac.jp

Affiliations Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, Laboratory of Oncology, Department of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji city, Tokyo, Japan

Jia Kim

Roles Formal analysis, Investigation, Validation, Visualization

Affiliations Laboratory of Oncology, Department of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji city, Tokyo, Japan, Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

Shintaro Hokaiwado

Roles Investigation, Validation, Visualization

Affiliations Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, Laboratory of Oncology, Department of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji city, Tokyo, Japan

Makiko Nawa

Roles Formal analysis, Investigation, Methodology, Resources

Affiliation Laboratory of Cytometry and Proteome Research in Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

Hayato Okamoto

Roles Investigation

Affiliation Laboratory of Oncology, Department of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji city, Tokyo, Japan

Tomohiko Kogiso

Roles Investigation

Affiliation Laboratory of Oncology, Department of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji city, Tokyo, Japan

Tetsuro Watabe

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Laboratory of Oncology, Department of Life Science, Tokyo University of Pharmacy and Life Sciences, Hachioji city, Tokyo, Japan, Department of Biochemistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan

Nobutaka Hattori

Roles Resources

Affiliation Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan

Competing Interests

TF and TW declare a grant from Daiichi-Sankyo Pharmaceutical Company outside the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.