About the Authors

K. R. Brown

Roles Data curation, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Department of Pediatrics, Division of Allergy and Immunology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America

R. Z. Krouse

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Rho Federal Systems Division Inc., Chapel Hill, North Carolina, United States of America

A. Calatroni

Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Rho Federal Systems Division Inc., Chapel Hill, North Carolina, United States of America

C. M. Visness

Roles Formal analysis, Investigation, Software, Writing – review & editing

Affiliation Rho Federal Systems Division Inc., Chapel Hill, North Carolina, United States of America

U. Sivaprasad

Roles Data curation, Methodology

Affiliation Department of Pediatrics, Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America

C. M. Kercsmar

Roles Investigation, Writing – review & editing

Affiliation Department of Pediatrics, Division of Pulmonary Medicine, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America

E. C. Matsui

Roles Investigation, Writing – review & editing

Affiliation Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

J. B. West

Roles Investigation, Writing – review & editing

Affiliation Boston University School of Medicine, Boston, Massachusetts, United States of America

M. M. Makhija

Roles Investigation, Writing – review & editing

Affiliation Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States of America

M. A. Gill

Roles Investigation, Writing – review & editing

Affiliation University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

H. Kim

Roles Investigation, Writing – review & editing

Affiliation Henry Ford Health System, Detroit, Michigan, United States of America

M. Kattan

Roles Investigation, Writing – review & editing

Affiliation College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

D. Pillai

Roles Investigation, Writing – review & editing

Affiliation Children’s National Health System, Washington, District of Columbia, United States of America

J. E. Gern

Roles Investigation, Writing – review & editing

Affiliation University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

W. W. Busse

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

A. Togias

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, United States of America

A. H. Liu

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations National Jewish Health, Denver, Colorado, United States of America, Children’s Hospital Colorado and University of Colorado School of Medicine, Aurora, Colorado, United States of America

G. K. Khurana Hershey

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – review & editing

gurjit.hershey@cchmc.org

Affiliation Department of Pediatrics, Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, United States of America

Competing Interests

Glaxo SmithKline (GSK) (www.gsk.com) provided Ventolin, Flovent, Advair and Flonase under a clinical trial agreement with NIH NIAID. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.