About the Authors

Satomi Yagi

Contributed equally to this work with: Satomi Yagi, Yasuhiro Koh

Affiliations Medical Business Unit, Hitachi Chemical Co., Ltd., Ibaraki, Japan, Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Yasuhiro Koh

Contributed equally to this work with: Satomi Yagi, Yasuhiro Koh

ykoh@wakayama-med.ac.jp

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Hiroaki Akamatsu

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Kuninobu Kanai

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Atsushi Hayata

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Nahomi Tokudome

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Keiichiro Akamatsu

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Katsuya Endo

Affiliation Medical Business Unit, Hitachi Chemical Co., Ltd., Ibaraki, Japan

Seita Nakamura

Affiliation Medical Business Unit, Hitachi Chemical Co., Ltd., Ibaraki, Japan

Masayuki Higuchi

Affiliation Medical Business Unit, Hitachi Chemical Co., Ltd., Ibaraki, Japan

Hisashige Kanbara

Affiliation Medical Business Unit, Hitachi Chemical Co., Ltd., Ibaraki, Japan

Masanori Nakanishi

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Hiroki Ueda

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Nobuyuki Yamamoto

Affiliation Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan

Competing Interests

YK received research funding from Daiichi Sankyo. SY, KE, SN, MH and HK are employed by Hitachi Chemical Co., Ltd. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: YK NY. Data curation: SY YK. Formal analysis: SY HA. Funding acquisition: YK NY. Investigation: SY YK HA NY. Methodology: SY YK KE SN. Project administration: YK HA NY. Resources: SY YK HA KK AH NT KA KE SN MH HK MN HU NY. Supervision: YK NY. Visualization: SY YK. Writing – original draft: SY YK. Writing – review & editing: SY YK HK NY.