Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress

Ker Woon Choy; Yeh Siang Lau; Dharmani Murugan; Mohd Rais Mustafa

doi:10.1371/journal.pone.0178365

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Open Access

Peer-reviewed

Research Article

Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress

Ker Woon Choy,

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
⨯
Yeh Siang Lau,

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
⨯
Dharmani Murugan,

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
⨯
Mohd Rais Mustafa

* E-mail: rais@um.edu.my

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

http://orcid.org/0000-0002-7864-5189

⨯

Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress

Ker Woon Choy,
Yeh Siang Lau,
Dharmani Murugan,
Mohd Rais Mustafa

Published: May 31, 2017
https://doi.org/10.1371/journal.pone.0178365

About the Authors

Ker Woon Choy

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Yeh Siang Lau

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Dharmani Murugan

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Mohd Rais Mustafa

* E-mail: rais@um.edu.my

Affiliation Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

http://orcid.org/0000-0002-7864-5189

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: KWC MRM YSL DM. Data curation: KWC. Formal analysis: KWC. Funding acquisition: MRM. Investigation: KWC. Methodology: KWC. Project administration: KWC. Resources: MRM. Software: MRM. Supervision: MRM YSL DM. Validation: MRM YSL DM. Visualization: MRM YSL DM. Writing – original draft: KWC. Writing – review & editing: MRM YSL DM.

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Aorta
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Endoplasmic reticulum
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Blood pressure
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Oxidative stress
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Nitric oxide
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Hypertension
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Transcription factors
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Superoxides
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