About the Authors

Tomoya Mukai

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Naohisa Hosomi

nhosomi@hiroshima-u.ac.jp

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Miwako Tsunematsu

Affiliation Department of Health Informatics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Yoshimasa Sueda

Affiliation Department of Neurology, National Hospital Organization Kure Medical Center, Kure, Japan

Yutaka Shimoe

Affiliation Department of Neurology, Brain Attack Center Ota Memorial Hospital, Fukuyama, Japan

Tomohiko Ohshita

Affiliation Department of Neurology, Suiseikai Kajikawa Hospital, Hiroshima, Japan

Tsuyoshi Torii

Affiliation Department of Neurology, National Hospital Organization Kure Medical Center, Kure, Japan

Shiro Aoki

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Tomohisa Nezu

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Hirofumi Maruyama

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Masayuki Kakehashi

Affiliation Department of Health Informatics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

Masayasu Matsumoto

Affiliation Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

on behalf of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators

Membership of the Hiroshima ‘Emergency and Weather’ Study-stroke collaborators is provided in the Acknowledgements.

Competing Interests

Dr. Hosomi reports an honorarium from Mochida Pharmaceutical Co., LTD., which is outside the scope of the submitted manuscript. Prof. Matsumoto reports grants from Mochida Pharmaceutical Co., LTD., Otsuka Pharmaceutical, and Daiichi Sankyo Co., LTD. and honoraria from Sanofi K.K., Bayer Health Care, Otsuka Pharmaceutical, Daiichi Sankyo Co., LTD., Boehringer Ingelheim, and Sumitomo Dainippon Pharma Co., LTD., which are outside the scope of the submitted work. The other authors declare no conflicts of interest. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: MK NH MM. Data curation: TM MT. Formal analysis: MT MK. Funding acquisition: NH MM. Investigation: TM NH Y. Sueda Y. Shimoe TO TT SA TN HM. Methodology: TM NH Y. Sueda. Resources: TM NH Y. Sueda Y. Shimoe TO TT SA TN HM. Supervision: MK MM. Validation: TM NH Y. Sueda Y. Shimoe TO TT SA TN HM. Visualization: TM NH. Writing – original draft: TM NH MT. Writing – review & editing: MK MM.