About the Authors

Emma Sullivan

Affiliation Adelphi Real World, Manchester, United Kingdom

James Piercy

Affiliation Adelphi Real World, Manchester, United Kingdom

John Waller

Affiliation Adelphi Real World, Manchester, United Kingdom

Christopher M. Black

Affiliation Merck & Co., Inc., Kenilworth, NJ, United States of America

Sumesh Kachroo

sumesh.kachroo@merck.com

Affiliation Merck & Co., Inc., Kenilworth, NJ, United States of America

Competing Interests

We have the following interests: John Waller, Emma Sullivan and James Piercy are employees of Adelphi Real World. Christopher Black and Sumesh Kachroo are employees of Merck & Co and hold stock and options. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: JW ES JP CB SK. Data curation: JW ES JP CB SK. Formal analysis: JW ES JP CB SK. Funding acquisition: JW ES JP CB SK. Investigation: JW ES JP CB SK. Methodology: JW ES JP CB SK. Project administration: JW ES JP CB SK. Resources: JW ES JP CB SK. Software: JW ES JP CB SK. Supervision: JW ES JP CB SK. Validation: JW ES JP CB SK. Visualization: JW ES JP CB SK. Writing – original draft: JW ES JP CB SK. Writing – review & editing: JW ES JP CB SK.