About the Authors

Frederick J. Krambeck

fjkrambeck@reactech.net

Affiliations Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, ReacTech Inc., Alexandria, Virginia, United States of America

Sandra V. Bennun

Current address: Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America

Affiliations Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America, ReacTech Inc., Alexandria, Virginia, United States of America

Mikael R. Andersen

Affiliation Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark

Michael J. Betenbaugh

Affiliation Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America

Competing Interests

Sandra V. Bennun is currently employed by Regeneron Pharmaceuticals Inc. The work described in the manuscript is unrelated to Dr. Bennun's duties at Regeneron. Frederick J. Krambeck is associated with ReacTech Inc., which is a pass-through entity to manage Dr. Krambeck's income from consulting and software licensing. Dr. Krambeck is a consultant in the areas of chemical process development and mathematical modeling, including glycosylation modeling. He also provides computer software useful in those areas for licensing. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: FJK SVB MRA MJB. Data curation: SVB. Formal analysis: FJK SVB. Funding acquisition: FJK SVB MJB. Investigation: FJK SVB MRA. Methodology: FJK. Project administration: FJK MJB. Resources: FJK SVB. Software: FJK. Supervision: FJK MJB. Validation: FJK SVB. Visualization: FJK SVB MJB. Writing – original draft: FJK SVB MRA. Writing – review & editing: FJK SVB MRA MJB.