Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach

Sneha P.; Thirumal Kumar D.; George Priya Doss C.; Siva R.; Hatem Zayed

doi:10.1371/journal.pone.0174953

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Open Access

Peer-reviewed

Research Article

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach

Sneha P.,

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India
⨯
Thirumal Kumar D.,

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India
⨯
George Priya Doss C. ,

* E-mail: georgepriyadoss@vit.ac.in (CGPD); hatem.zayed@qu.edu.qa (HZ)

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India
⨯
Siva R.,

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India
⨯
Hatem Zayed

* E-mail: georgepriyadoss@vit.ac.in (CGPD); hatem.zayed@qu.edu.qa (HZ)

Affiliation Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar
⨯

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach

Sneha P.,
Thirumal Kumar D.,
George Priya Doss C.,
Siva R.,
Hatem Zayed

Published: April 14, 2017
https://doi.org/10.1371/journal.pone.0174953

About the Authors

Sneha P.

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India

Thirumal Kumar D.

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India

George Priya Doss C.

* E-mail: georgepriyadoss@vit.ac.in (CGPD); hatem.zayed@qu.edu.qa (HZ)

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India

Siva R.

Affiliation School of BioSciences and Technology,Vellore Institute of Technology, Vellore, Tamil Nadu, India

Hatem Zayed

* E-mail: georgepriyadoss@vit.ac.in (CGPD); hatem.zayed@qu.edu.qa (HZ)

Affiliation Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: HZ GPDC. Data curation: SP TKD SR CGPD. Formal analysis: SP TKD SR CGPD. Funding acquisition: HZ. Investigation: SP SR TKD CGPD HZ. Methodology: SP SR CGPD. Project administration: CGPD HZ. Resources: SP SR TKD CGPD. Supervision: HZ CGPD. Validation: HZ CGPD. Visualization: SP CGPD. Writing – original draft: HZ CGPD TKD SP SR. Writing – review & editing: HZ CGPD.

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DNA-binding proteins
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Transcription factors
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Mutation databases
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Missense mutation
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Hydrogen bonding
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Arginine
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Salt bridges
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Biochemical simulations
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