About the Authors

Jihoon Kim

Contributed equally to this work with: Jihoon Kim, Chisato Shimizu

j5kim@ucsd.edu (JK); jcburns@ucsd.edu (JCB)

Affiliation Department of Biomedical Informatics, University of California San Diego, La Jolla, California, United States of America

Chisato Shimizu

Contributed equally to this work with: Jihoon Kim, Chisato Shimizu

Affiliation Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America

Stephen F. Kingsmore

Affiliation Rady Children’s Institute for Genomic Medicine, Rady Children’s Hospital, San Diego, California, United States of America

Narayanan Veeraraghavan

Affiliation Rady Children’s Institute for Genomic Medicine, Rady Children’s Hospital, San Diego, California, United States of America

Eric Levy

Affiliations Department of Biomedical Informatics, University of California San Diego, La Jolla, California, United States of America, Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, United States of America

Andre M. Ribeiro dos Santos

Affiliation Department of Biomedical Informatics, University of California San Diego, La Jolla, California, United States of America

Hai Yang

Affiliation Department of Biomedical Informatics, University of California San Diego, La Jolla, California, United States of America

Jay Flatley

Affiliation Illumina, San Diego, California, United States of America

Long Truong Hoang

Affiliation Genome Institute of Singapore, Singapore, Singapore

Martin L. Hibberd

Affiliation Depatment of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

Adriana H. Tremoulet

Affiliations Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America, Rady Children’s Hospital San Diego, San Diego, California, United States of America

Olivier Harismendy

Affiliations Department of Biomedical Informatics, University of California San Diego, La Jolla, California, United States of America, Moores Cancer Center, University of California San Diego, La Jolla, California, United States of America

Lucila Ohno-Machado

Affiliation Department of Biomedical Informatics, University of California San Diego, La Jolla, California, United States of America

Jane C. Burns

j5kim@ucsd.edu (JK); jcburns@ucsd.edu (JCB)

Affiliations Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America, Rady Children’s Hospital San Diego, San Diego, California, United States of America

Competing Interests

Whole genome sequencing was donated by Jay Flatley who was the CEO of Illumina at that time. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: JK CS JCB. Data curation: JK CS HY LTH. Formal analysis: JK CS SFK NV OH. Funding acquisition: LOM JCB. Investigation: JK CS EL LTH AHT JCB. Methodology: JK CS SFK JCB. Project administration: LOM JCB. Resources: JK CS SFK NV AHT JF. Software: JK NV. Supervision: SFK LOM JCB. Validation: CS EL AMR. Visualization: JK CS. Writing – original draft: JK CS JCB. Writing – review & editing: JK CS SFK MLH OH LOM JCB.