About the Authors

Wouter W. Kallemeijn

Affiliations Department of Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Saskia Scheij

Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Sascha Hoogendoorn

Current address: Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California, United States of America

Affiliation Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Martin D. Witte

Current address: Department of Bio-Organic Chemistry, Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands

Affiliation Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Daniela Herrera Moro Chao

Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Cindy P. A. A. van Roomen

Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Roelof Ottenhoff

Affiliation Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Herman S. Overkleeft

Affiliation Department of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Rolf G. Boot

Affiliations Department of Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Johannes M. F. G. Aerts

j.m.f.g.aerts@lic.leidenuniv.nl

Affiliations Department of Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Competing Interests

JMFGA and HSO are inventors on a patent application on cyclophellitol epoxide ABPs. The name of the patent is "Activity Based Probes (ABPS0 interacting with glycosidases)" and the patent number is US 9,056,847 B2 (date of patent: June 16, 2015). There are no further patents, products in development or marketed products to declare. The remaining authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: WWK JMFGA. Data curation: WWK SS SH CPAAVR RO. Formal analysis: WWK SS SH RGB JMFGA. Funding acquisition: HSO JMFGA. Investigation: WWK SS SH DHMC CPAAVR RO RGB JMFGA. Methodology: WWK RGB JMFGA. Project administration: JMFGA. Resources: SS SH MDW CPAAVR RO HSO. Software: WWK SH. Supervision: RGB JMFGA. Validation: WWK SS RGB JMFGA. Visualization: WWK SH RGB JMFGA. Writing – original draft: WWK JMFGA. Writing – review & editing: WWK SS SH HSO RGB JMFGA.