Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106

Tao Luo; Han Liu; Jin Kyung Kim

doi:10.1371/journal.pone.0167761

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Open Access

Peer-reviewed

Research Article

Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106

Tao Luo,

Affiliation Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America
⨯
Han Liu,

Affiliation Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America
⨯
Jin Kyung Kim

* E-mail: jkim13@uci.edu

Affiliation Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America
⨯

Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106

Tao Luo,
Han Liu,
Jin Kyung Kim

Published: December 8, 2016
https://doi.org/10.1371/journal.pone.0167761

About the Authors

Tao Luo

Affiliation Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America

Han Liu

Affiliation Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America

Jin Kyung Kim

* E-mail: jkim13@uci.edu

Affiliation Division of Cardiology, Department of Medicine, School of Medicine, University of California Irvine, Irvine, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: JK. Formal analysis: TL HL. Funding acquisition: JK. Investigation: TL HL JK. Methodology: JK TL HL. Project administration: JK. Resources: JK. Supervision: JK. Validation: HL TL. Visualization: TL HL. Writing – original draft: TL HL JK. Writing – review & editing: JK.

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Mitochondria
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Heart
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Cardiomyocytes
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Threonine
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Cardiac ventricles
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Estrogens
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Mouse models
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Superoxide dismutase
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