About the Authors

Kana Tsukuda

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Masaki Mogi

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Jun Iwanami

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Harumi Kanno

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Hirotomo Nakaoka

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Xiao-Li Wang

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Hui-Yu Bai

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Bao-Shuai Shan

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Masayoshi Kukida

Affiliations Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan, Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Akinori Higaki

Affiliations Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan, Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Toshifumi Yamauchi

Affiliations Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan, Department of Pediatrics, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Li-Juan Min

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Masatsugu Horiuchi

horiuchi@m.ehime-u.ac.jp

Affiliation Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University, Graduate School of Medicine, Tohon, Ehime, Japan

Competing Interests

This study was supported by JSPS KAKENHI [Grant Number 25293310 to MH, 25462220 to MM, 15K19974 to JI, and 26860567 to LJM] and research grants from pharmaceutical companies: Ajinomoto Pharmaceuticals Co. Ltd., Astellas PharmaInc., Bayer Yakuhin Ltd., Daiichi-Sankyo Pharmaceutical Co. Ltd., Nippon Boehringer Ingelheim Co. Ltd., Novartis Pharma K. K., Shionogi & Co. Ltd., and Takeda Pharmaceutical Co. Ltd. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceptualization: MM MH. Data curation: KT. Formal analysis: KT JI HN. Funding acquisition: MM JI LJM MH. Investigation: KT JI HK HN XLW HYB BSS MK AH TY LJM. Methodology: MM KT MH. Project administration: MM MH. Resources: MM KT JI HK HN XLW HYB BSS MK AH TY LJM. Supervision: MH. Validation: JI. Visualization: MM KT JI LJM MH. Writing – original draft: MM KT MH. Writing – review & editing: MM KT JI HK HN XLW HYB BSS MK AH TY LJM MH.