About the Authors

Sunil C. Kaul

Affiliation Drug Discovery and Assets Innovation Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan

Yoshiyuki Ishida

Affiliation CycloChem Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe, Japan

Kazuya Tamura

Affiliation DAI-DAN Co., Ltd., 390 Kitanagai, Miyoshi-machi, Iruma-gun, Saitama, Japan

Teruo Wada

Affiliation Osaka Prefecture University, 1-1 Nakakugakuencho, Sakai-city, Osaka, Japan

Tomoko Iitsuka

Affiliation Drug Discovery and Assets Innovation Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan

Sukant Garg

Affiliations Drug Discovery and Assets Innovation Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan, School of Integrative and Global Majors, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan

Mijung Kim

Affiliation Drug Discovery and Assets Innovation Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan

Ran Gao

Affiliation Drug Discovery and Assets Innovation Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan

Shoichi Nakai

Affiliation DAI-DAN Co., Ltd., 390 Kitanagai, Miyoshi-machi, Iruma-gun, Saitama, Japan

Youji Okamoto

Affiliation Zuiron Private Ltd., 2-3-1 Nakajyosanjimacho, Tokushima-city, Tokushima, Japan

Keiji Terao

Affiliation CycloChem Co., Ltd., 7-4-5 Minatojima-minamimachi, Chuo-ku, Kobe, Japan

Renu Wadhwa

renu-wadhwa@aist.go.jp

Affiliations Drug Discovery and Assets Innovation Laboratory, DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Japan, School of Integrative and Global Majors, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan

Competing Interests

Dr. Yoshiyuki Ishida and Dr. Keiji Terao are research employees of CycloChem Co., Ltd. Mr. Kazuya Tamura and Mr. Shoichi Nakai are employee of DAI-DAN Co., Ltd. Dr. Youji Okamoto is an employee of Zuiron Private Ltd. There are no products in development or marketed products to declare. We would like to add that a part of the extraction method is in patent application – under consideration. Details are as follows: (WO2015115512) METHOD FOR PREPARING WATER EXTRACT OF ASHWAGANDHA LEAVES WHICH HAS ENHANCED ANTI-CANCER ACTIVITY UTILIZING CYCLODEXTRIN, AND PHARMACEUTICAL COMPOSITION CONTAINING ASHWAGANDHA LEAVES (https://patentscope2.wipo.int/search/en/detail.jsf?docId=WO2015115512); Pub. No. WO/2015/115512; International Application No.: PCT/JP2015/052431; Publication Date: 06.08.2015; International Filing Date: 29.01.2015. This does not alter our adherence to PLOS One policies on sharing data and materials.

Author Contributions

Conceptualization: SCK YI TW YO K. Terao RW. Data curation: SCK YI TW SG MK RW. Formal analysis: SCK YI TW TI SG MK RG RW. Funding acquisition: SCK TW SN YO K. Terao RW. Investigation: SCK YI TW TI SG MK RG RW. Methodology: SCK YI K. Tamura TW TI SG MK RG SN YO K. Terao RW. Project administration: SCK YI TW K. Terao RW. Resources: SCK TW SN YO K. Terao RW. Supervision: SCK TW K. Terao RW. Validation: SCK YI K. Tamura TW TI SG MK RG K. Terao RW. Visualization: SCK YI TW K. Terao RW. Writing – original draft: SCK YI TW RW. Writing – review & editing: SCK YI TW K. Terao RW.