About the Authors

Mario Santos

Affiliations Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America, Department of Physiology and Cardiothoracic Surgery, Cardiovascular R&D Unit, Faculty of Medicine, University of Porto, Porto, Portugal

Dalane W. Kitzman

Affiliation Wake Forest Baptist Medical Center, Winston Salem, NC, United States of America

Kunihiro Matsushita

Affiliation Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America

Laura Loehr

Affiliation University of North Carolina, Chapel Hill, NC, United States of America

Carla A. Sueta

Affiliation University of North Carolina, Chapel Hill, NC, United States of America

Amil M. Shah

ashah11@partners.org

Affiliation Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, United States of America

Competing Interests

Dr Shah reports receiving research support from Novartis, Actelion Pharmaceuticals Ltd, and Gilead. The other authors have no disclosures. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: MS AMS. Formal analysis: MS AMS. Methodology: MS AMS. Supervision: AMS. Writing – original draft: MS AMS. Writing – review & editing: DWK KM LL CAS.