Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition

Katherine A. Aiello; Orly Alter

doi:10.1371/journal.pone.0164546

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Open Access

Peer-reviewed

Research Article

Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition

Katherine A. Aiello,

Affiliations Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America, Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America
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Orly Alter

* E-mail: orly@sci.utah.edu

Affiliations Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America, Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America, Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America
⨯

Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition

Katherine A. Aiello,
Orly Alter

Published: October 31, 2016
https://doi.org/10.1371/journal.pone.0164546

About the Authors

Katherine A. Aiello

Orly Alter

* E-mail: orly@sci.utah.edu

Affiliations Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, United States of America, Department of Bioengineering, University of Utah, Salt Lake City, Utah, United States of America, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America, Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America

Competing Interests

OA is a co-founder of and an equity holder in Eigengene, Inc. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: KAA OA. Data curation: KAA OA. Formal analysis: KAA OA. Funding acquisition: OA. Investigation: KAA OA. Methodology: KAA OA. Project administration: OA. Resources: KAA OA. Software: KAA OA. Supervision: OA. Validation: KAA OA. Visualization: KAA OA. Writing – original draft: KAA OA. Writing – review & editing: KAA OA.

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Cancers and neoplasms
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Astrocytoma
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Cancer genomics
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Malignant tumors
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Cancer treatment
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Human genomics
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DNA methylation
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Laboratory tests
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